Movement Disorder Evaluation

Important

This report is intended to assist qualified Health Care Profesionals (HCP) in the assessment of an individual referred under the suspicion of having Parkinson’s Disease.

Clinical Context

This report presents several AI metrics derived from objective measures from individuals performing a battery of test using Manus Neurodynamica NeuroMotor PenTM.

These presented metrics combine factors from detailed measurement recordings made whilst the individual performs a battery of well established neurological test tasks.

The metrics have been assessed in a UK reference population and an individual’s results are presented in this clinical context. The HCP should review Clinical,Reference, Study et al [1] to establish applicability and limitations.

The information in this report should be used in the context of a full neurological assessment conducted to the current standard of care practices to establish a diagnosis.

Subject and Recording Details

Subject ID NMC017
Sex MALE
Dominant hand LEFT
Test administered by neuromedic@manusdevices.net
Test date and time 2022-12-21 13:38
Test battery Circle, Spiral, Elel, FITTS Short Modified, FITTS Long Modified, ZigZag, ZigZag Offset
Operator comment tbl Madopar a 250mg 1/2+1/4+1/2+1/4 caps Madopar HBS a 125mg jedna uvece old patient

Overall Assessment

PD

Subject performance similar to PD population (recommend review of report details)

Clinical context

In the clinical reference population, 2 individuals with a value less than 0.51 were subsequently diagnosed with PD. That is, 4.76% of the PD diagnoses in the study.

Additionally, 0 individuals with a value greater or equal to 0.51 were subsequently diagnosed as non PD. That is, 0.0% of the non PD diagnoses in the study.

Symptom Scores

These mini boxplots show the scores in a clinical context. Currently against the ‘Walker study’ data. A bigger pool would be much better (so max 83 individuals, usually lower if raw data did not result in successful classification).

The scores are ‘relative to the PD cohort’ and this is how they should be interpreted. A consequence of this is that a low tremor score below may actually correspond to obvious tremor in the raw data, and vice versa.

Micrographia

The micrographia symptom assessment is derived from a combination of factors in the elel task.

{'FN': 31, 'TN': 24, 'TP': 11, 'FP': 6}

Tremor

The tremor score is a combination of features in the circle, spiral and both zizag tasks.

{'FN': 24, 'TN': 20, 'TP': 18, 'FP': 10}

Bradykinesia

The bradykinesia score is a combination of features in the circle, spiral, both zizag and elel tasks.

{'FN': 5, 'TN': 2, 'TP': 37, 'FP': 28}

Spatial Accuracy

The accuracy score is a combination of factors in the spiral, both zigzags and both Fitts tasks.

{'FN': 11, 'TN': 8, 'TP': 31, 'FP': 22}

Test Battery Details

Circle

numCircles 10
timePerCircleMean 5.824
timePerCircleCoV 0.142502
timePerCircleSlope 0.00241425
meanError 1.8852
tremorFreq 6.73828
tremorRelPower 22.3726
tremorGyroAmpMean 0.017648
tremorGyroAmpSlope -0.0166399
tremorGyroAmpCoV 0.522101
tremorCoordAmpMean 0.039603
tremorCoordAmpSlope -0.00521411
tremorCoordAmpCoV 0.300165
tremorAccAmpMean 0.0258953
tremorAccAmpSlope -0.00410785
tremorAccAmpCoV 0.461617
tremorPcRelVar 0.657335
tremorPcX 0.77741
tremorPcY 0.628995

Circle Segment 1

Duration 5.76 s, Accuracy Estimate 2.109 (lower is better)

Circle Segment 2

Duration 5.44 s, Accuracy Estimate 1.488 (lower is better)

Circle Segment 3

Duration 5.0 s, Accuracy Estimate 1.613 (lower is better)

Circle Segment 4

Duration 5.2 s, Accuracy Estimate 1.774 (lower is better)

Circle Segment 5

Duration 7.88 s, Accuracy Estimate 1.599 (lower is better)

Circle Segment 6

Duration 5.84 s, Accuracy Estimate 1.68 (lower is better)

Circle Segment 7

Duration 6.4 s, Accuracy Estimate 1.99 (lower is better)

Circle Segment 8

Duration 5.92 s, Accuracy Estimate 2.034 (lower is better)

Circle Segment 9

Duration 5.56 s, Accuracy Estimate 2.073 (lower is better)

Circle Segment 10

Duration 5.24 s, Accuracy Estimate 2.492 (lower is better)

Spiral

numSpirals 10
timePerSpiralMean 16.196
timePerSpiralCoV 0.0706312
timePerSpiralSlope 0.0171385
meanError 1.88435
tremorFreq 7.91016
tremorRelPower 19.5667
tremorGyroAmpMean 0.0176465
tremorGyroAmpSlope 0.00118631
tremorGyroAmpCoV 0.557771
tremorCoordAmpMean 0.0497022
tremorCoordAmpSlope 0.00153612
tremorCoordAmpCoV 0.393092
tremorAccAmpMean 0.0343065
tremorAccAmpSlope 0.00254407
tremorAccAmpCoV 0.521955
tremorPcRelVar 0.682074
tremorPcX -0.733521
tremorPcY -0.679667

Spiral Segment 1

Duration 15.48 s, Accuracy Estimate 1.583 (lower is better)

Spiral Segment 2

Duration 15.64 s, Accuracy Estimate 1.975 (lower is better)

Spiral Segment 3

Duration 15.32 s, Accuracy Estimate 1.785 (lower is better)

Spiral Segment 4

Duration 14.72 s, Accuracy Estimate 1.924 (lower is better)

Spiral Segment 5

Duration 16.32 s, Accuracy Estimate 1.914 (lower is better)

Spiral Segment 6

Duration 16.92 s, Accuracy Estimate 2.018 (lower is better)

Spiral Segment 7

Duration 14.96 s, Accuracy Estimate 1.95 (lower is better)

Spiral Segment 8

Duration 16.92 s, Accuracy Estimate 1.858 (lower is better)

Spiral Segment 9

Duration 17.92 s, Accuracy Estimate 1.787 (lower is better)

Spiral Segment 10

Duration 17.76 s, Accuracy Estimate 2.051 (lower is better)

Elel

eDurationMean 0.485294
eDurationStd 0.0867331
eDurationStdnorm 0.178723
eDurationMedian 0.465
eDurationQuartdelta 0.075
eDurationQuartdeltanorm 0.16129
eDurationKurt 2.83721
eDurationTrenddiff -0.07
eDurationTrendratio 0.862745
eWidthMean 4.27394
eWidthStd 0.898572
eWidthStdnorm 0.210244
eWidthMedian 4.095
eWidthQuartdelta 0.936
eWidthQuartdeltanorm 0.228571
eWidthKurt 4.87492
eWidthTrenddiff -0.819
eWidthTrendratio 0.825
eHeightMean 10.4887
eHeightStd 1.82416
eHeightStdnorm 0.173917
eHeightMedian 10.3545
eHeightQuartdelta 2.691
eHeightQuartdeltanorm 0.259887
eHeightKurt 2.08661
eHeightTrenddiff -1.521
eHeightTrendratio 0.858696
eAspectMean 0.414359
eAspectStd 0.0947786
eAspectStdnorm 0.228736
eAspectMedian 0.403409
eAspectQuartdelta 0.107711
eAspectQuartdeltanorm 0.267001
eAspectKurt 5.02291
eAspectTrenddiff -0.016998
eAspectTrendratio 0.958567
eSlantMean -0.158909
eSlantStd 0.167286
eSlantStdnorm -1.05272
eSlantMedian -0.152311
eSlantQuartdelta 0.256511
eSlantQuartdeltanorm -1.68413
eSlantKurt 2.75295
eSlantTrenddiff -0.0477296
eRtopMean 0.578269
eRtopStd 0.225467
eRtopStdnorm 0.389899
eRtopMedian 0.616667
eRtopQuartdelta 0.386364
eRtopQuartdeltanorm 0.626536
eRtopKurt 2.00083
eRtopTrenddiff 0.0333333
eRbotMean 0.988668
eRbotStd 0.390051
eRbotStdnorm 0.394522
eRbotMedian 0.978261
eRbotQuartdelta 0.528958
eRbotQuartdeltanorm 0.540712
eRbotKurt 5.00885
eRbotTrenddiff 0.18227
eRrightMean 0.844624
eRrightStd 0.095874
eRrightStdnorm 0.113511
eRrightMedian 0.851015
eRrightQuartdelta 0.147624
eRrightQuartdeltanorm 0.173468
eRrightKurt 2.38069
eRrightTrenddiff 0.0464321
eRleftMean 0.581015
eRleftStd 0.179753
eRleftStdnorm 0.309378
eRleftMedian 0.611746
eRleftQuartdelta 0.268442
eRleftQuartdeltanorm 0.438812
eRleftKurt 2.50289
eRleftTrenddiff -0.0933333
lDurationMean 0.660313
lDurationStd 0.123373
lDurationStdnorm 0.18684
lDurationMedian 0.6325
lDurationQuartdelta 0.14
lDurationQuartdeltanorm 0.221344
lDurationKurt 3.26762
lDurationTrenddiff -0.065
lDurationTrendratio 0.904762
lWidthMean 5.08584
lWidthStd 1.41058
lWidthStdnorm 0.277355
lWidthMedian 4.9725
lWidthQuartdelta 1.4625
lWidthQuartdeltanorm 0.294118
lWidthKurt 3.5865
lWidthTrenddiff -0.351
lWidthTrendratio 0.933333
lHeightMean 21.3964
lHeightStd 4.20809
lHeightStdnorm 0.196673
lHeightMedian 22.113
lHeightQuartdelta 3.5685
lHeightQuartdeltanorm 0.161376
lHeightKurt 5.72096
lHeightTrenddiff -2.574
lHeightTrendratio 0.89
lAspectMean 0.251339
lAspectStd 0.10299
lAspectStdnorm 0.409767
lAspectMedian 0.241504
lAspectQuartdelta 0.0687619
lAspectQuartdeltanorm 0.284723
lAspectKurt 6.75861
lAspectTrenddiff 0.0167089
lAspectTrendratio 1.07304
lSlantMean -0.163913
lSlantStd 0.124755
lSlantStdnorm -0.761106
lSlantMedian -0.160799
lSlantQuartdelta 0.147187
lSlantQuartdeltanorm -0.915346
lSlantKurt 2.65622
lSlantTrenddiff -0.0587495
lRtopMean 0.59137
lRtopStd 0.211796
lRtopStdnorm 0.358145
lRtopMedian 0.63573
lRtopQuartdelta 0.343512
lRtopQuartdeltanorm 0.540342
lRtopKurt 2.30297
lRtopTrenddiff -0.0784347
lRbotMean 1.3879
lRbotStd 0.753522
lRbotStdnorm 0.542922
lRbotMedian 1.22132
lRbotQuartdelta 0.6818
lRbotQuartdeltanorm 0.558249
lRbotKurt 7.07575
lRbotTrenddiff 0.105284
lRrightMean 0.793328
lRrightStd 0.121262
lRrightStdnorm 0.152853
lRrightMedian 0.816441
lRrightQuartdelta 0.208383
lRrightQuartdeltanorm 0.255233
lRrightKurt 2.33955
lRrightTrenddiff -0.079818
lRleftMean 0.625106
lRleftStd 0.144131
lRleftStdnorm 0.23057
lRleftMedian 0.605073
lRleftQuartdelta 0.179956
lRleftQuartdeltanorm 0.297412
lRleftKurt 2.20696
lRleftTrenddiff 0.0916508

Elel Segment 1

Elel Segment 2

Elel Segment 3

Elel Segment 4

Elel Segment 5

Elel Segment 6

Elel Segment 7

Elel Segment 8

Elel Segment 9

Elel Segment 10

Elel Segment 11

Elel Segment 12

Elel Segment 13

Elel Segment 14

Elel Segment 15

FITTS Short Modified

meanTouchScore 0.783228
sumTouchScores 18.7975
meanMovementTime 0.796957
numTouches 24
undershootPercentage 8.33333
overshootPercentage 25

FITTS Long Modified

meanTouchScore 0.916159
sumTouchScores 18.3232
meanMovementTime 0.984737
numTouches 20
undershootPercentage 5
overshootPercentage 0

ZigZag

numZigzags 5
timePerZigzagMean 18.584
timePerZigzagCoV 0.0874119
timePerZigzagSlope 0.00753336
meanError 2.36627
tremorFreq 6.73828
tremorRelPower 23.8274
tremorGyroAmpMean 0.0215528
tremorGyroAmpSlope -0.00252742
tremorGyroAmpCoV 0.357732
tremorCoordAmpMean 0.0603151
tremorCoordAmpSlope -0.0024647
tremorCoordAmpCoV 0.287153
tremorAccAmpMean 0.0466956
tremorAccAmpSlope -0.00185878
tremorAccAmpCoV 0.335078
tremorPcRelVar 0.713927
tremorPcX -0.342199
tremorPcY 0.939627

ZigZag Segment 1

Duration 16.76 s, Accuracy Estimate 2.428 (lower is better)

ZigZag Segment 2

Duration 18.84 s, Accuracy Estimate 2.19 (lower is better)

ZigZag Segment 3

Duration 20.92 s, Accuracy Estimate 2.17 (lower is better)

ZigZag Segment 4

Duration 19.04 s, Accuracy Estimate 2.466 (lower is better)

ZigZag Segment 5

Duration 17.36 s, Accuracy Estimate 2.577 (lower is better)

ZigZag Offset

numZigzags 5
timePerZigzagMean 13.584
timePerZigzagCoV 0.0775062
timePerZigzagSlope -0.0229682
zigzagHeightMean 73.4513
zigzagHeightCoV 0.0525621
zigzagHeightSlope -0.0028009
meanError 0.0366505
tremorFreq 6.54297
tremorRelPower 23.3407
tremorGyroAmpMean 0.0472918
tremorGyroAmpSlope 0.00255457
tremorGyroAmpCoV 0.400288
tremorCoordAmpMean 0.107479
tremorCoordAmpSlope 0.00371113
tremorCoordAmpCoV 0.286864
tremorAccAmpMean 0.0835227
tremorAccAmpSlope 0.00206774
tremorAccAmpCoV 0.260595
tremorPcRelVar 0.739967
tremorPcX -0.374131
tremorPcY -0.927376

ZigZag Offset Segment 1

Duration 13.44 s, Accuracy Estimate 0.036 (lower is better)

ZigZag Offset Segment 2

Duration 14.6 s, Accuracy Estimate 0.023 (lower is better)

ZigZag Offset Segment 3

Duration 13.48 s, Accuracy Estimate 0.029 (lower is better)

ZigZag Offset Segment 4

Duration 14.44 s, Accuracy Estimate 0.033 (lower is better)

ZigZag Offset Segment 5

Duration 11.96 s, Accuracy Estimate 0.062 (lower is better)

Appendices

Misc

Currently a dumping ground for things that could be included or previous output style.

Note

Putting all the results out here but will not be in a final report.

HiSpec {‘HiSpec_class’: ‘NOT PD’, ‘HiSpec_score’: 0.89}
RanFor {‘RanFor_class’: ‘PD’, ‘RanFor_score’: 0.51}
BM_May22 {‘BM_May22_class’: ‘PD’, ‘BM_May22_score’: 0.019070978613117573}
BM_HC_Sep22 {‘BM_HC_Sep22_class’: ‘Patient’, ‘BM_HC_Sep22_score’: 0.7171850707321432}
BM_PD_Sep22 {‘BM_PD_Sep22_class’: ‘nonPD’, ‘BM_PD_Sep22_score’: 0.464004602582781}